Fuming Zhang

Fuming Zhang

Research Professor

Glycobiology, Glycoenginnering, SPR

After eight years of teaching and research in Biochemical Engineering and Fermentation Technology at the Zhejiang University of Technology, Zhang went to the University of Leeds as a Ph.D. student to study in Microbiology. He joined the Linhardt Group at the University of Iowa in 1999, after he worked in Hong Kong University of Science and Technology (HKUST) for one year as a research associate. Zhang moved to RPI with the Linhardt Group in 2003. Fuming Zhang has published more than 130 research papers and received several scientific achievement awards (such as Research Excellent Award, RPI, 2012; the Zhejiang Provincial Government Scientific Achievement Awards, 1993). He serves editorial board members for Journal of Biomedical Technology and Research (since 2013) and Journal of Biotechnology and Bioengineering (since 2014)

Education

Ph.D. Microbiology (University of Leeds, Leeds City, UK, 1997) B.E. Biochemical Engineering (HuaQiao University, China, 1986)

Selected Publications

  • Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities. (2004)
  • Heparin accelerates gelsolin amyloidogenesis. (2006)
  • Microscale isolation and analysis of heparin from plasma using an anion-exchange spin column. (2006)
  • Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction. (2006)
  • Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway. (2007)
  • Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization. (2005)
  • Affinity, kinetic, and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate. (2006)
  • Structural analysis on heparin/heparan sulfate interacting with FGF•FGFR complexes (2009)
  • Chemical structure characterization of commercial heparin from different commercial sources (2011)
  • Analysis of the Interaction between Heparin and Follistatin/Follistatin-ligand complexes Using Surface Plasmon Resonance (2012)
  • Characterization of Interactions between Heparin/Glycosaminoglycan and Adeno-associated Virus (2013)
  • Probing the impact of GFP tagging on Robo1-heparin interaction (2014)