Optical Tweezers - MMI Laser Microdissection

Example of data produced by optical tweezers

Optical tweezers are capable of measuring picoNewton forces involved in single molecule dynamics and interactions (e.g. proteins & nucleic acids), while the laser microdissection setup can isolate tissue, single cells, or even submolecular structures (e.g. chromosomes); isolated material can then be prepared for genomic or proteomic analysis.

MMI CellCut/CellManipulator optical tweezers at Rensselaer
MMI CellCut/CellManipulator

The MMI CellCut/CellManipulator system is mounted on an Olympus IX-71 microscope with a motorized stage and CCD camera. Differential Interference Contrast and widefield fluorescence modalities are available. Laser microdissection is performed with a 355nm laser; a touch screen makes selecting regions of interest for microdissection simple. The optical tweezers use a 1064 YAG infrared laser with 3W trapping power that can be split (time-share mode) to trap up to 10 different objects. Dual quadrant detectors are available for detection.

Manufacturer: Asylum Research MFP 3D AFM
Equipment Rates & Fees
  RPI Users External
Non-Profit
External Industry External Industry Partners
Standard $27 $44 $89 $80
Assisted $54 $89 $178 $160
Training $69 $114 $227 $204
  RPI Users External Nonprofit External Industry External Industry Partners
Personnel Time $60 $99 $197 $178

Valid through July 31, 2022. Rates are hourly unless specified otherwise and are subject to change without further notice.

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Please acknowledge the CBIS Core Facilities in all publications and grant applications where our equipment and/or personnel have facilitated the work. These acknowledgements are very important because documenting our contributions helps to ensure that the resources of the Core Facilities are sustainable.

  • Equipment: If you used Core Facility equipment, please note this in the Materials and Methods. e.g., Thermogravimetric analysis was carried out using a TA Instruments TGA-Q50 (Rensselaer CBIS Analytical Biochemistry Core Facility).
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