CBIS Research Faculty
Research Faculty at CBIS
Robert J. Linhardt

Robert J. Linhardt

Ann and John H. Broadbent, Jr. ’59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering

Glycoscience, Biocatalysis, Metabolic Engineering, Nanobiotechnology, Analytical Chemistry, Chemoenzymatic Synthesis

Robert J. Linhardt received his Ph.D. degree from the Johns Hopkins University (1979) and was a postdoctoral student with Professor Robert Langer at the Massachusetts Institute of Technology (1979-1982) and served on the faculty of University of Iowa from 1982-2003. He is currently the Ann and John H. Broadbent, Jr.'59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering at Rensselaer Polytechnic Institute, holding joint appointments in the Departments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering, and Biomedical Engineering. He is an Adjunct Professor of Orthopedics at the Icahn School of Medicine, Mount Sinai, NY. His honors include the American Chemical Society Horace S. Isbell, Claude S. Hudson and Melville L. Wolfrom Awards, the AACP Volwiler Research Achievement Award, the USP Award for an Innovative Response to a Public Health Challenge, is a fellow of the National Academy of Inventors (NAI), a Fellow of the AAAS, and one of the Scientific American Top 10. His research focuses on glycobiology, glycochemistry and glycoengineering. He has recently been actively involved in the emerging field of nanobiotechnology and is focused on developing an artificial Golgi and cellulose-based energy storage devices. Professor Linhardt has published over 740 peer-reviewed manuscripts and holds over 50 patents.


Marquette University, B.S. 1975 Chemistry The Johns Hopkins University M.A., Ph.D. 1977, 1979 Organic Chemistry Massachusetts Institute of Technology Postdoctoral 1979-1982 Biochemical Engineering

Selected Publications

  • Rapid generation of CRISPR/dCas9-regulated, orthogonally repressible hybrid T7-lac promoters for modular, tuneable control of metabolic pathway fluxes in E. coli, B. Cress, J. Jones, K. Daniel, Q. Leitz, J. Englaender, S. Collins, R. J. Linhardt, M. Koffas, Nucleic Acids Research, in press, 2016.
  • Urinary glycosaminoglycans predict outcomes in septic shock and ARDS, E. P. Schmidt, K. H. Overdier, X. Sun, L. Lin, X. Liu, Y. Yang, L. A. Ammons, T. D. Hiller, M. A. Suflita, Y. Yu, Y. Chen, F. Zhang, C. Cothren Burlew, C. L. Edelstein, I. S. Douglas, R. J. Linhardt, American Journal of Respiratory and Critical Care Medicine, in press, 2016.
  • Bioengineered heparins and heparan sulfates, L. Fu, M. Suflita, R. J. Linhardt, Advanced Drug Delivery Reviews, 97, 237–249, 2016.
  • Green solvents in carbohydrate chemistry: from raw materials to fine chemicals, A. Farrán, C. Cai, M. Sandoval, Y. Xu, J. Liu, M. J. Hernáiz, R. J. Linhardt, Chemical Reviews, 115, 6811-6853, 2015.
  • Glycosaminoglycanomics of cultured cells using a rapid and sensitive LC-MS/MS approach, G. Li, F. Tian, L. Zhang, C. Xue, L. Li, R. J. Linhardt, ACS Chemical Biology, 10, 1303-1310, 2015.
  • Click-coated, heparinized, decellularized vascular grafts, S. Dimitrievska, C. Cai, A. Weyers, T. Lin, S. Sundaram, D. A. Spiegel, T. R. Kyriakides, J. Miao, G. Li, L. Niklason, R. J. Linhardt, Acta Biomateriala, 13, 177–187, 2015.
  • Homogeneous low-molecular-weight heparins with reversible anticoagulant activity, Y. Xu, C. Cai, K. Chandarajoti, P.-H. Hsieh, L.Li, T. Q. Pham, E. M. Sparkenbaugh, J. Sheng, N. S. Key, R. Pawlinski, E. N. Harris, R.J. Linhardt, J. Liu, Nature Chemical Biology, 10, 248-250, 2014.
  • The proteoglycan bikunin has a defined sequence, M. Ly, F. E. Leach III, T. N. Laremore, T. Toida, I. J. Amster, R.J. Linhardt, Nature Chemical Biology, 7, 827-833, 2011.
  • Chemoenzymatic synthesis of structurally homogeneous ultralow molecular weight heparins, Y. Xu, S. Masuko, M. Takieddin, H. Xu, R. Liu, J. Jing, S. Mousa, R. J. Linhardt, J. Liu, Science, 334, 498-501, 2011.