CBIS Facilities
Research Faculty at CBIS

Isothermal Titration Calorimeter (ITC)

MicroCal VP-ITC

Isothermal Titration Calorimetry allows a simultaneous determination of all binding parameters (equilibrium constant, enthalpy of binding and stoichiometry of the interaction) in a single experiment - information unobtainable from more limited binding assays.

Main Technical Features

  • The range of binding constants is broad: K from sub-millimolar to nanomolar (102 to 109 M-1).
  • It is a true in-solution technique: No labeling or immobilization is required.
  • Active cell volume ~ 1.4 ml.
  • Non-reactive Hastelloy® cells for excellent chemical resistance.
  • Fixed-in-place cells for reproducible ultrasensitive performance with low maintenance.
  • Precision liquid delivery system for accurate and reproducible injections.
  • Operating temperature range of 2ºC to 80ºC.
  • Peltier controlled for rapid temperature equilibration.
  • Includes ThermoVac® sample preparation and cleaning device.
  • Includes Single Injection Method and ITC-Expert software.


  • Characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules.
  • Assessment of the effect of molecular structure changes on binding mechanisms.
  • Assessment of biological activity.
Rates & Fees: 

Rates are hourly and are subject to change without further notice.  
Valid through July 31, 2019.

  RPI Users External Nonprofit External Industry External Industry Partners
Approved $15 $24 $49 $44
Assisted $30 $49 $97 $87
Training $62 $100 $201 $181
Personnel Time $52 $84 $168 $152